Direct Determination of Glyphosate and Its Metabolites in Foods of Animal Origin by Liquid Chromatography-Tandem Mass Spectrometry.

ABSTRACT: Glyphosate is the most used herbicide in agriculture. Its major metabolite is AMPA (aminomethylphosphonic acid), but N-acetyl-AMPA and N-acetylglyphosate are also metabolites of interest. For risk assessment, a general residue definition was proposed as the sum of glyphosate, AMPA, N-acetyl-glyphosate and N-acetyl-AMPA, expressed as glyphosate. A confirmatory method for glyphosate in fat, liver and kidneys, as well as a confirmatory method for AMPA and N-acetyl-glyphosate in all matrices, are still missing. In this paper, we present a method for the quantitative determination of glyphosate residues and its metabolites AMPA, N-acetyl-AMPA and N-acetyl-glyphosate by liquid chromatography-mass spectrometry (LC-MS/MS) in adipose tissue, liver, eggs, milk and honey without derivatization. Diffe

SUBMITTER: Denzic Lugomer M 

PROVIDER: S-EPMC11311992 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature