Age-Related Retinal Layer Thickness Changes Measured by OCT in APP^NL-F/NL-F Mice: Implications for Alzheimer's Disease.

ABSTRACT: In Alzheimer's disease (AD), transgenic mouse models have established links between abnormalities in the retina and those in the brain. APP^NL-F/NL-F is a murine, humanized AD model that replicates several pathological features observed in patients with AD. Research has focused on obtaining quantitative parameters from optical coherence tomography (OCT) in AD. The aim of this study was to analyze, in a transversal case-control study using manual retinal segmentation via SD-OCT, the changes occurring in the retinal layers of the APP^NL/F-NF/L AD model in comparison to C57BL/6J mice (WT) at 6, 9, 12, 15, 17, and 20 months of age. The analysis focused on retinal thickness in RNFL-GCL, IPL, INL, OPL, and ONL based on the Early Treatment Diabetic Retinopathy St

SUBMITTER: Sanchez-Puebla L 

PROVIDER: S-EPMC11312090 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature