The Cryptosporidium signaling kinase CDPK5 plays an important role in male gametogenesis and parasite virulence.

ABSTRACT: The protozoan parasite Cryptosporidium is a leading cause of diarrhea in young children. The parasite's life cycle involves a coordinated and timely progression from asexual to sexual stages, leading to the formation of the transmissible oocyst. Underlying molecular signaling mechanisms orchestrating sexual development are not known. Here, we describe the function of a signaling kinase in Cryptosporidium male gametogenesis. We reveal the expression of Cryptosporidium parvum calcium-dependent protein kinase 5 (CDPK5) during male gamete development and its important role in the egress of mature gametes. Genetic ablation of this kinase results in viable parasites, indicating that this gene is dispensable for parasite survival. Interestingly, cdpk5 deletion decreases parasite virulence and imp

SUBMITTER: Nava MG 

PROVIDER: S-EPMC11312397 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature