Para-Hydroxycinnamic Acid Mitigates Senescence and Inflammaging in Human Skin Models.

ABSTRACT: Para-hydroxycinnamic acid (pHCA) is one of the most abundant naturally occurring hydroxycinnamic acids, a class of chemistries known for their antioxidant properties. In this study, we evaluated the impact of pHCA on different parameters of skin aging in in vitro skin models after H₂O₂ and UV exposure. These parameters include keratinocyte senescence and differentiation, inflammation, and energy metabolism, as well as the underlying molecular mechanisms. Here we demonstrate that pHCA prevents oxidative stress-induced premature senescence of human primary keratinocytes in both 2D and 3D skin models, while improving clonogenicity in 2D. As aging is linked to inflammation, referred to as inflammaging, we analyzed the release of IL-6, IL-8, and PGE₂, kno

SUBMITTER: Tan CYR 

PROVIDER: S-EPMC11312399 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature