Intratumoral Microbiome: Foe or Friend in Reshaping the Tumor Microenvironment Landscape?

ABSTRACT: The role of the microbiome in cancer and its crosstalk with the tumor microenvironment (TME) has been extensively studied and characterized. An emerging field in the cancer microbiome research is the concept of the intratumoral microbiome, which refers to the microbiome residing within the tumor. This microbiome primarily originates from the local microbiome of the tumor-bearing tissue or from translocating microbiome from distant sites, such as the gut. Despite the increasing number of studies on intratumoral microbiome, it remains unclear whether it is a driver or a bystander of oncogenesis and tumor progression. This review aims to elucidate the intricate role of the intratumoral microbiome in tumor development by exploring its effects on reshaping the multileveled ecosystem in which tu

SUBMITTER: Kyriazi AA 

PROVIDER: S-EPMC11312414 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature