Polo-like kinase 1 prevents excess microtubule polymerization in <i>C. elegans</i> oocytes to ensure faithful meiosis.

ABSTRACT: Sexual reproduction relies on meiosis, a specialized cell division program that produces haploid gametes. Oocytes of most organisms lack centrosomes, and therefore chromosome segregation is mediated by acentrosomal spindles. Here, we explore the role of Polo-like kinase 1 (PLK-1) in C. elegans oocytes, revealing mechanisms that ensure the fidelity of this unique form of cell division. Previously, PLK-1 was shown to be required for nuclear envelope breakdown and chromosome segregation in oocytes. We now find that PLK-1 is also required for establishing and maintaining acentrosomal spindle organization and for preventing excess microtubule polymerization in these cells. Additionally, our studies revealed an unexpected new role for this essential kinase. While PLK-1 is known to be requ

SUBMITTER: Narula JG 

PROVIDER: S-EPMC11312516 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature