Event boundaries drive norepinephrine release and distinctive neural representations of space in the rodent hippocampus.

ABSTRACT: Episodic memories are temporally segmented around event boundaries that tend to coincide with moments of environmental change. During these times, the state of the brain should change rapidly, or reset, to ensure that the information encountered before and after an event boundary is encoded in different neuronal populations. Norepinephrine (NE) is thought to facilitate this network reorganization. However, it is unknown whether event boundaries drive NE release in the hippocampus and, if so, how NE release relates to changes in hippocampal firing patterns. The advent of the new GRAB_NE sensor now allows for the measurement of NE binding with sub-second resolution. Using this tool in mice, we tested whether NE is released into the dorsal hippocampus during event boundaries defined

SUBMITTER: McKenzie S 

PROVIDER: S-EPMC11312532 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature