Conservation, alteration, and redistribution of mammalian striatal interneurons.

ABSTRACT: Mammalian brains vary in size, structure, and function, but the extent to which evolutionarily novel cell types contribute to this variation remains unresolved^1-4. Recent studies suggest there is a primate-specific population of striatal inhibitory interneurons, the TAC3 interneurons⁵. However, there has not yet been a detailed analysis of the spatial and phylogenetic distribution of this population. Here, we profile single cell gene expression in the developing pig (an ungulate) and ferret (a carnivore), representing 94 million years divergence from primates, and assign newborn inhibitory neurons to initial classes first specified during development⁶. We find that the initial class of TAC3 interneurons represents an ancestral striatal population that is al

SUBMITTER: Corrigan EK 

PROVIDER: S-EPMC11312536 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature