Longitudinal Decline of Exercise Capacity in Male and Female Mice.

ABSTRACT: The population of older adults is exponentially expanding. Alongside aging comes the onset of chronic disease, decline of functional capacity, and reduced quality of life. Thus, this population increase will stress the capacity and financial viability of health and long-term care systems. Developing pre-clinical models for age-related functional decline is imperative to advancing therapies that extend healthspan and prolong independence. Previously in a cross-sectional study, we established a powerful composite scoring system we termed CFAB (comprehensive functional assessment battery). CFAB measures physical function and exercise capacity using well-validated determinants to measure overall motor function, fore-limb strength, four-limb strength/endurance, aerobic capacity, and volitional

SUBMITTER: Pajski ML 

PROVIDER: S-EPMC11312590 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature