Endothelial Immunosuppression in Atherosclerosis : Translational Control by Elavl1/HuR.

ABSTRACT: Atherosclerotic plaques are defined by the accumulation of lipids and immune cells beneath the endothelium of the arterial intima. CD8 T cells are among the most abundant immune cell types in plaque, and conditions linked to their activation correlate with increased levels of cardiovascular disease. As lethal effectors of the immune response, CD8 T cell activation is suppressed at multiple levels. These checkpoints are critical in dampening autoimmune responses, and limiting damage in cardiovascular disease. Endothelial cells are well known for their role in recruiting CD8 T and other hematopoietic cells to low and disturbed flow (LDF) arterial regions that develop plaque, but whether they locally influence CD8 effector functions is unclear. Here, we show that endothelial cells can activel

SUBMITTER: Nicholas SE 

PROVIDER: S-EPMC11312609 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature