Investigating the Role of Neighborhood Socioeconomic Status and Germline Genetics on Prostate Cancer Risk.

ABSTRACT:

Background

Genetic factors play an important role in prostate cancer (PCa) development with polygenic risk scores (PRS) predicting disease risk across genetic ancestries. However, there are few convincing modifiable factors for PCa and little is known about their potential interaction with genetic risk. We analyzed incident PCa cases (n=6,155) and controls (n=98,257) of European and African ancestry from the UK Biobank (UKB) cohort to evaluate the role of neighborhood socioeconomic status (nSES)-and how it may interact with PRS-on PCa risk.

Methods

We evaluated a multi-ancestry PCa PRS containing 269 genetic variants to understand the association of germline genetics with PCa in UKB. Using the English Indices of Deprivation, a set of validated metrics that quantify lack of r

SUBMITTER: Judd J 

PROVIDER: S-EPMC11312637 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature