Shared Genetic Liability across Systems of Psychiatric and Physical Illness.

ABSTRACT: Epidemiological literature has shown that there are extensive comorbidity patterns between psychiatric and physical illness. However, our understanding of the multivariate systems of relationships underlying these patterns is poorly understood. Using Genomic SEM and Genomic E-SEM, an extension for genomic exploratory factor analysis that we introduce and validate, we evaluate the extent to which latent genomic factors from eight domains, encompassing 76 physical outcomes across 1.9 million cases, evince genetic overlap with previously identified psychiatric factors. We find that internalizing, neurodevelopmental, and substance use factors are broadly associated with increased genetic risk sharing across all physical illness domains. Conversely, we find that a compulsive factor is protectiv

SUBMITTER: Lawrence JM 

PROVIDER: S-EPMC11312649 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature