Medications that Regulate Gastrointestinal Transit Influence Inpatient Blood Glucose.

ABSTRACT:

Objective

A multitude of factors affect a hospitalized individual's blood glucose (BG), making BG difficult to predict and manage. Beyond medications well established to alter BG, such as beta-blockers, there are likely many medications with undiscovered effects on BG variability. Identification of these medications and the strength and timing of these relationships has potential to improve glycemic management and patient safety.

Materials and methods

EHR data from 103,871 inpatient encounters over 8 years within a large, urban health system was used to extract over 500 medications, laboratory measurements, and clinical predictors of BG. Feature selection was performed using an optimized Lasso model with repeated 5-fold cross-validation on the 80% training set, followed by a

SUBMITTER: Momenzadeh A 

PROVIDER: S-EPMC11312652 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature