Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant <i>Enterococcus faecium</i>.

ABSTRACT: Vancomycin-resistant Enterococcus faecium (VREfm) is a prevalent healthcare-acquired pathogen. Gastrointestinal colonization can lead to difficult-to-treat bloodstream infections with high mortality rates. Prior studies have investigated VREfm population structure within healthcare centers. However, little is known about how and why hospital-adapted VREfm populations change over time. We sequenced 710 healthcare-associated VREfm clinical isolates from 2017-2022 from a large tertiary care center as part of the Enhanced Detection System for Healthcare-Associated Transmission (EDS-HAT) program. Although the VREfm population in our center was polyclonal, 46% of isolates formed genetically related clusters, suggesting a high transmission rate. We compared our collection to 15,631 publicl

SUBMITTER: Mills EG 

PROVIDER: S-EPMC11312660 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature