Biological Properties of Oleanolic Acid Derivatives Bearing Functionalized Side Chains at C-3.

ABSTRACT: Triterpene acids are a class of pentacyclic natural carboxylic compounds endowed with a variety of biological activities including antitumor, antimicrobial, and hepatoprotective effects. In this work, several oleanolic acid derivatives were synthesized by structurally modifying them on the C-3 position. All synthesized derivatives were evaluated for possible antibacterial and antiviral activity, and among all the epimers, 6 and 7 demonstrated the best biological activities. Zone-of-inhibition analyses were conducted against two strains, E. coli as a Gram-negative and S. aureus as a Gram-positive model. Subsequently, experiments were performed using the microdilution method to determine the minimum inhibitory concentration (MIC). The results showed that only the

SUBMITTER: Fontana G 

PROVIDER: S-EPMC11312724 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature