Trajectories of Sacubitril/Valsartan Adherence Among Medicare Beneficiaries With Heart Failure.

ABSTRACT:

Background

Sacubitril/valsartan, an angiotensin receptor/neprilysin inhibitor (ARNi), improves heart failure (HF) outcomes, yet real-world adherence patterns are not well understood.

Objectives

The purpose of this study was to analyze longitudinal patterns of adherence to ARNis in patients with HF and to identify factors associated with adherence patterns.

Methods

Using Medicare beneficiaries from 2015 to 2018, we included patients diagnosed with HF who initiated an ARNi. A group-based trajectory model was constructed to identify adherence patterns during follow-up. We used multivariable logistic regression to investigate factors associated with membership in each adherence trajectory group.

Results

Among 9,475 eligible beneficiaries (age 77 ± 7 years, 34% fema

SUBMITTER: Huang W 

PROVIDER: S-EPMC11312759 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature