Untargeted lipidomics reveals racial differences in lipid species among women.

ABSTRACT: Understanding the biological mechanisms underlying racial differences in diseases is crucial to developing targeted prevention and treatment. There is, however, limited knowledge of the impact of race on lipids. To address this, we performed comprehensive lipidomics analyses to evaluate racial differences in lipid species among 506 non-Hispanic White (NHW) and 163 non-Hispanic Black (NHB) women. Plasma lipidomic profiling quantified 982 lipid species. We used multivariable linear regression models, adjusted for confounders, to identify racial differences in lipid species and corrected for multiple testing using a Bonferroni-adjusted p-value < 10^-5. We identified 248 lipid species that were significantly associated with race. NHB women had lower levels of several lipid species, m

SUBMITTER: Pourali G 

PROVIDER: S-EPMC11312829 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature