Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues.

ABSTRACT: Background: Obesity and overweight are also becoming more prevalent among women of childbearing age and pregnant women. In maternal obesity, the activation of metabolic, inflammatory, and oxidative stress pathways is proven, which appears to be a key step in the pathological changes observed in placental and uterine function. Several recent studies have evidenced that aquaporins (AQPs) are critical players in adipose tissue biology and are involved in the onset of obesity. Methods: Our studies aimed to investigate the changes in placental volume and vascularization and measure the AQP5 expression and total antioxidant capacity (TAC) in the placenta and uterus tissues in obese and typical-weight mothers. We also aim to measure the AQP5 plasma concentration. Results: We

SUBMITTER: Kemeny KK 

PROVIDER: S-EPMC11312882 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature