Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching.

ABSTRACT: The branched architecture of neuronal dendrites is a key factor in how neurons form ordered networks and discoveries continue to be made identifying proteins and protein-protein interactions that direct or execute the branching and extension of dendrites. Our prior work showed that the molecular scaffold Pdlim5 and delta-catenin, in conjunction, are two proteins that help regulate the branching and elongation of dendrites in cultured hippocampal neurons and do so through a phosphorylation-dependent mechanism triggered by upstream glutamate signaling. In this report we have focused on Pdlim5's multiple scaffolding domains and how each contributes to dendrite branching. The three identified regions within Pdlim5 are the PDZ, DUF, and a trio of LIM domains; however, unresolved is the intra-mo

SUBMITTER: Srivastava Y 

PROVIDER: S-EPMC11312917 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature