The genetics and epidemiology of N- and O-immunoglobulin A glycomics.

ABSTRACT:

Background

Immunoglobulin (Ig) glycosylation modulates the immune response and plays a critical role in ageing and diseases. Studies have mainly focused on IgG glycosylation, and little is known about the genetics and epidemiology of IgA glycosylation.

Methods

We generated, using a novel liquid chromatography-mass spectrometry method, the first large-scale IgA glycomics dataset in serum from 2423 twins, encompassing 71 N- and O-glycan species.

Results

We showed that, despite the lack of a direct genetic template, glycosylation is highly heritable, and that glycopeptide structures are sex-specific, and undergo substantial changes with ageing. We observe extensive correlations between the IgA and IgG glycomes, and, exploiting the twin design, show that they are predomin

SUBMITTER: Visconti A 

PROVIDER: S-EPMC11312925 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature