A case of response to combination treatment with TSA-DC-CTL immunotherapy and osimertinib in EGFR mutated advanced lung adenocarcinoma.

ABSTRACT:

Background

This study details a case of a patient with advanced lung adenocarcinoma harboring an exon 19 deletion in the EGFR gene.

Method

A 46-year-old female patient was diagnosed with stage IVb left lung adenocarcinoma, with multiple bone and lymph node metastases. Following the identification of tumor-specific antigen peptides, the patient received a combination treatment of immunotherapy (TSA-DC-CTL) and oral osimertinib. Peripheral blood circulating immune cells and circulating tumor cells (CTCs) were monitored before and after treatment. PET-CT and CT scans were used to assess the tumor response to treatment.

Results

A significant increase in total lymphocyte percentage and decrease in the number of CTCs in the patient was observed. Imaging studies showed a not

SUBMITTER: Han Z 

PROVIDER: S-EPMC11313023 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature