The Oxygen Cascade According to HFpEF Likelihood: A Focus on Sex Differences.

ABSTRACT:

Background

Women are at greater risk for heart failure with preserved ejection fraction (HFpEF).

Objectives

The aim of the study was to compare sex differences in the pathophysiology of exertional breathlessness in patients with high vs low HFpEF likelihood.

Methods

This cohort study evaluated consecutive patients (n = 1,936) with unexplained dyspnea using cardiopulmonary exercise testing and simultaneous echocardiography and quantified peak oxygen uptake (peak VO₂) and its determinants. HFpEF was considered likely when the H₂FPEF or HFA-PEFF score was ≥6 or ≥5, respectively. Sex differences were evaluated with the Student's t-test or Mann-Whitney U test and determinants of exercise capacity with a multivariable linear regression.

SUBMITTER: Verwerft J 

PROVIDER: S-EPMC11313028 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature