Low-Penetrance Susceptibility Variants in Colorectal Cancer-Current Outlook in the Field.

ABSTRACT: Colorectal cancer (CRC) is one of the most frequent and mortality-causing neoplasia, with various distributions between populations. Strong hereditary predispositions are the causatives of a small percentage of CRC, and most cases have no transparent genetic background. This is a vast arena for exploring cancer low-susceptibility genetic variants. Nonetheless, the research that has been conducted to date has failed to deliver consistent conclusions and often features conflicting messages, causing chaos in this field. Therefore, we decided to organize the existing knowledge on this topic. We screened the PubMed and Google Scholar databases. We drew up markers by gene locus gathered by hallmark: oncogenes, tumor suppressor genes, genes involved in DNA damage repair, genes involved in metabol

SUBMITTER: Szuman M 

PROVIDER: S-EPMC11313073 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature