Glycolysis-related genes predict prognosis and indicate immune microenvironment features in gastric cancer.

ABSTRACT:

Background

Gastric cancer (GC) is a major contributor to cancer-related mortality. Glycolysis plays a pivotal role in tumor microenvironment (TME) reprogramming. In this research, the functions of glycolysis-associated genes (GRGs) were evaluated to predict the outcome and reveal the characteristics of the immune microenvironment in individuals with stomach cancer.

Methods

The Cancer Genome Atlas (TCGA)-stomach adenocarcinoma (STAD) cohort provided gene expression and clinical data for gastric cancer (GC) patients, which were further authenticated using datasets sourced from the Gene Expression Omnibus (GEO). By referencing the Molecular Signatures Database (MSigDB), a total of 326 GRGs were pinpointed. The various subtypes of GC were outlined through consensus clustering, d

SUBMITTER: Xu L 

PROVIDER: S-EPMC11313097 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature