The relationship between cortical thickness and white matter hyperintensities in mid to late life.

ABSTRACT: White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26-50 years) and relatively older (58-84) participants who were free of dementia, and how these associations are moderated by WMH localization. WMH were automatically quantified and categorized according to the localization of three classes of white matter tracts: association, commissural and projection fibers. Mediation analyses were used to infer whether differences in cortical thickness between younger and older participants were explained by WMH. Our results revealed that total WMH explained between 20.6 %

SUBMITTER: Jimenez-Balado J 

PROVIDER: S-EPMC11313098 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature