Proteomic Analysis Reveals Physiological Activities of Aβ Peptide for Alzheimer's Disease.

ABSTRACT: With the rapid progress in deciphering the pathogenesis of Alzheimer's disease (AD), it has been widely accepted that the accumulation of misfolded amyloid β (Aβ) in the brain could cause the neurodegeneration in AD. Although much evidence demonstrates the neurotoxicity of Aβ, the role of Aβ in the nervous system are complex. However, more comprehensive studies are needed to understand the physiological effect of Aβ₄₀ monomers in depth. To explore the physiological mechanism of Aβ, we employed mass spectrometry to investigate the altered proteomic events induced by a lower submicromolar concentration of Aβ. Human neuroblastoma SH-SY5Y cells were exposed to five different concentrations of Aβ_1-40 monomers and collected at four time points. The proteomic analysis reveal

SUBMITTER: Ai X 

PROVIDER: S-EPMC11313142 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature