Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank.

ABSTRACT:

Background

During the course of adulthood and aging, white matter (WM) structure and organization are characterized by slow degradation processes such as demyelination and shrinkage. An acceleration of such aging processes has been linked to the development of a range of diseases. Thus, an accurate description of healthy brain maturation, particularly in terms of WM features, is fundamental to the understanding of aging.

Methods

We used longitudinal diffusion magnetic resonance imaging to provide an overview of WM changes at different spatial and temporal scales in the UK Biobank (UKB) (n = 2678; age_{scan 1} = 62.38 ± 7.23 years; age_{scan 2} = 64.81 ± 7.1 years). To examine the genetic overlap between WM structure and common clinical conditions, we t

SUBMITTER: Korbmacher M 

PROVIDER: S-EPMC11313202 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature