Identification of Catecholamine and Drug Target α_2A-Adrenoceptor in Human Testis and Human Testicular Peritubular Cells.

ABSTRACT: Background: Clonidine has been used in clinical medicine, e.g., to treat high blood pressure and other conditions. Animal studies have linked its use to impairments of male reproductive functions, and although only a few reports exist for the human species, such actions may exist in man as well. The underlying reasons and, specifically, possible actions of clonidine at the level of the testis are not known. Introduction: Clonidine is an agonist at the α_2A-adrenoceptor (ADRA2A), which, as data bank mining indicated, is expressed by several cells of the human testis. The human testis and most of its cells are, however, not readily accessible to experimental testing. Cells from the peritubular wall compartment (human testicular peritubular cells; HTPCs) are the except

SUBMITTER: Harald W 

PROVIDER: S-EPMC11313226 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature