Cell-Free DNA Analysis of Fetal Aneuploidies in Early Pregnancy Loss.

ABSTRACT: Background: Products of conception samples are often collected and analyzed to try to determine the cause of an early pregnancy loss. However, sample collection may not always be possible, and maternal cell contamination and culture failure can affect the analysis. Cell-free DNA-based analysis of a blood sample could be used as an alternative method in early pregnancy loss cases to detect if aneuploidies were present in the fetus. Methods: In this prospective study, blood samples from early pregnancy loss patients were analyzed for the presence of fetal aneuploidies using a modified version of a noninvasive prenatal testing assay for cell-free DNA analysis. Results from cell-free DNA analysis were compared against the gold standard, microarray analysis of products of concepti

SUBMITTER: Kutteh WH 

PROVIDER: S-EPMC11313239 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature