Comprehensive Transcriptome Analysis Expands lncRNA Functional Profiles in Breast Cancer.

ABSTRACT: Breast cancer is a heterogeneous disease that arises as a multi-stage process involving multiple cell types. Patients diagnosed with the same clinical stage and pathological classification may have different prognoses and therapeutic responses due to alterations in molecular genetics. As an essential marker for the molecular subtyping of breast cancer, long non-coding RNAs (lncRNAs) play a crucial role in gene expression regulation, cell differentiation, and the maintenance of genomic stability. Here, we developed a modular framework for lncRNA identification and applied it to a breast cancer cohort to identify novel lncRNAs not previously annotated. To investigate the potential biological function, regulatory mechanisms, and clinical relevance of the novel lncRNAs, we elucidated the genom

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11313538 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature