Apoptosis and Inflammation Involved with Fluoride-Induced Bone Injuries.

ABSTRACT:

Background

Excessive fluoride exposure induces skeletal fluorosis, but the specific mechanism responsible is still unclear. Therefore, this study aimed to identify the pathogenesis of fluoride-induced bone injuries.

Methods

We systematically searched fluoride-induced bone injury-related genes from five databases. Then, these genes were subjected to enrichment analyses. A TF (transcription factor)-mRNA-miRNA network and protein-protein interaction (PPI) network were constructed using Cytoscape, and the Human Protein Atlas (HPA) database was used to screen the expression of key proteins. The candidate pharmacological targets were predicted using the Drug Signature Database.

Results

A total of 85 studies were included in this study, and 112 osteoblast-, 35 osteoclast-, a

SUBMITTER: Wang M 

PROVIDER: S-EPMC11313706 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature