C₃-Alkylation of Imidazo[1,2-a]pyridines via Three-Component Aza-Friedel-Crafts Reaction Catalyzed by Y(OTf)₃.

ABSTRACT: As an important class of nitrogen-containing fused heterocyclic compounds, imidazo[1,2-a]pyridines often exhibit significant biological activities, such as analgesic, anticancer, antiosteoporosis, anxiolytic, etc. Using Y(OTf)₃ as a Lewis acid catalyst, a simple and efficient method has been developed for the synthesis of C₃-alkylated imidazo[1,2-a]pyridines through the three-component aza-Friedel-Crafts reaction of imidazo[1,2-a]pyridines, aldehydes, and amines in the normal air atmosphere without the protection of inert gas and special requirements for anhydrous and anaerobic conditions. A series of imidazo[1,2-a]pyridine derivatives were obtained with moderate to good yields, and their structures were confirmed by ¹H NMR, ¹³C NMR, and HRMS. Fu

SUBMITTER: Yang K 

PROVIDER: S-EPMC11313794 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature