Causal Relationship between Meat Intake and Biological Aging: Evidence from Mendelian Randomization Analysis.

ABSTRACT: Existing research indicates that different types of meat have varying effects on health and aging, but the specific causal relationships remain unclear. This study aimed to explore the causal relationship between different types of meat intake and aging-related phenotypes. This study employed Mendelian randomization (MR) to select genetic variants associated with meat intake from large genomic databases, ensuring the independence and pleiotropy-free nature of these instrumental variables (IVs), and calculated the F-statistic to evaluate the strength of the IVs. The validity of causal estimates was assessed through sensitivity analyses and various MR methods (MR-Egger, weighted median, inverse-variance weighted (IVW), simple mode, and weighted mode), with the MR-Egger regression intercept u

SUBMITTER: Liu S 

PROVIDER: S-EPMC11313912 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature