Green Synthesis and Antifungal Activities of Novel N-Aryl Carbamate Derivatives.

ABSTRACT: Carbamate is a key structural motif in the development of fungicidal compounds, which is still promising and robust in the discovery of green pesticides. Herein, we report the synthesis and evaluation of the fungicidal activity of 35 carbamate derivatives, among which 19 compounds were synthesized in our previous report. These derivatives were synthesized from aromatic amides in a single step, which was a green oxidation process for Hofmann rearrangement using oxone, KCl and NaOH. Their chemical structures were characterized by ¹H NMR, ¹³C NMR and high-resolution mass spectrometry. Their antifungal activity was tested against seven plant fungal pathogens. Many of the compounds exhibited good antifungal activity in vitro (inhibitory rate > 60% at 50 μg/mL). Compound

SUBMITTER: Liu X 

PROVIDER: S-EPMC11313961 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature