Total Syntheses and Stereochemical Assignment of Acremolides A and B.

ABSTRACT: The absolute stereochemical configurations of acremolides A and B were predicted by a biochemistry-based rule and unambiguously confirmed through their total syntheses. The features of the total syntheses include sequential Krische's Ir-catalyzed crotylation, Brown's borane-mediated crotylation, Mitsunobu esterification reaction, and cross-metathesis reaction. The efficient total synthesis enabled clear validation of the predicted stereochemistry for acremolides A and B.

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC11314444 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature