Functionalizing Thiosemicarbazones for Covalent Conjugation.

ABSTRACT: Thiosemicarbazones (TSCs) with their modular character (thiosemicarbazides + carbonyl compound) allow broad variation of up to four substituents on the main R¹R²C=N(1)-NH-C(S)-N(4)R³R⁴ core and are thus interesting tools for the formation of conjugates or the functionalization of nanoparticles (NPs). In this work, di-2-pyridyl ketone was introduced for the coordination of metals and 9-anthraldehyde for luminescence as R¹ and R² to TSCs. R³ and R⁴ substituents were varied for the formation of conjugates. Amino acids were introduced at the N4 position to produce [R¹R²TSC-spacer-amino acid] conjugates. Further, functions such as phosphonic acid (R-P(O)(OH)₂), D

SUBMITTER: Hohnsen J 

PROVIDER: S-EPMC11314635 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature