Identification of Potential Drug Targets for Myopia Through Mendelian Randomization.

ABSTRACT:

Purpose

The purpose of this study was to identify potential drug targets for myopia and explore underlying mechanisms.

Methods

Mendelian randomization (MR) was implemented to assess the effect of 2684 pharmacologically targetable genes in the blood and retina on the risk of myopia from a genomewide association study (GWAS) for age-at-onset of spectacle wearing-inferred mean spherical equivalent (MSE; discovery cohort, N = 287,448, European), which was further validated in a GWAS for autorefraction-measured MSE (replication cohort, N = 95,619, European). The reliability of the identified significant potential targets was strengthened by colocalization analysis. Additionally, enrichment analysis, protein-protein interaction network, and molecular docking were performed to expl

SUBMITTER: Qin Y 

PROVIDER: S-EPMC11314700 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature