Single-cell transcriptomic analysis uncovers heterogeneity in the labial gland microenvironment of primary Sjogren's syndrome.

ABSTRACT:

Objective

Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder with an unclear pathogenetic mechanism in the labial gland. This study aims to investigate the cellular and molecular mechanisms contributing to the development of this disease.

Methods

Single-cell RNA sequencing (scRNA-seq) was performed on 32,337 cells of labial glands from three pSS patients and three healthy individuals. We analyzed all cell subsets implicated in pSS pathogenesis.

Results

Our research revealed diminished differentiation among epithelial cells, concomitant with an enhancement of interferons (IFNs)-mediated signaling pathways. This indicates a cellular functional shift in reaction to inflammatory triggers. Moreover, we observed an augmentation in the population of myofibrob

SUBMITTER: Huang J 

PROVIDER: S-EPMC11314884 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature