Exploring the genetic association between immune cells and susceptibility to osteonecrosis using large-scale population data.

ABSTRACT:

Objectives

Research shows a close association between aberrant immune reactions in osteonecrotic tissues and immune cell infiltration. However, due to limitations in sample size and dataset comprehensiveness, the causal relationship between them is not fully established. This study aims to determine whether there is a causal relationship using a larger and more diverse dataset.

Methods

We conducted a comprehensive Mendelian Randomization (MR) analysis to investigate the causal relationship between immune cell characteristics and osteonecrosis. Utilizing publicly available genetic data, we explored the causal relationships between 731 immune cell features and 604 cases from the FinnGen Finnish database, as well as 257 cases from the UK Biobank database with osteonecrosis data

SUBMITTER: Meng C 

PROVIDER: S-EPMC11315082 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature