Interleukin-33 links asthma to alopecia areata: Mendelian randomization and mediation analysis.

ABSTRACT:

Objective

The objective of this study is to elucidate the causal association between asthma and alopecia areata (AA) through the application of Mendelian randomization (MR) analysis, leveraging summary data from genome-wide association studies (GWAS). Additionally, it explores potential mediating factors.

Materials and methods

Mendelian randomization (MR) analysis was employed to investigate the causal relationship between asthma and AA using genetic instrumental variables (IVs) for asthma, 91 circulating inflammatory proteins, and AA extracted from large-scale GWAS. The primary analytical approach utilized the inverse-variance weighted (IVW) method, supplemented by weighted median and MR-Egger methods to assess robustness. Tests for heterogeneity and pleiotropy were conduct

SUBMITTER: Wu P 

PROVIDER: S-EPMC11315093 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature