Repurposing anti-osteoporosis drugs for autoimmune diseases: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Despite the increasing availability of therapeutic drugs for autoimmune diseases, many patients still struggle to achieve their treatment goals. Our aim was to identify whether drugs originally used to treat bone density could be applied to the treatment of autoimmune diseases through Mendelian randomization (MR).

Methods

Using summary statistics from genome-wide association studies, we used a two-sample MR design to estimate the correlation between autoimmune diseases and BMD-related drug targets. Data from the DrugBank and ChEMBL databases were used to identify the drug targets of anti-osteoporosis medications. The Wald ratio test or inverse-variance weighting method was used to assess the impact of genetic variation in drug target(s) on autoimmune disease thera

SUBMITTER: Xiang P 

PROVIDER: S-EPMC11315135 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature