Titanium dioxide nanoparticles Disrupt ultrastructure and function of Rat thyroid tissue via oxidative stress.

ABSTRACT: Nano-TiO₂ is widely used in various fields such as industry, daily necessities, food and medicine. Previous studies have shown that it can enter mammalian tissues through the digestive tract or respiratory tract and have effects on various organs and systems. However, the effect of nano-TiO₂ on the mammalian thyroid gland has not been reported. In this study, we fed SD rats with rutile nano-TiO₂ at a dose of 5 mg/kg body weight for 3 weeks, and then examined the thyroid histology and thyroid function of the rats. In vitro experiments were conducted to determine the effects of nano-TiO₂ on the viability, apoptosis, inflammatory factors, antioxidant enzymes, and oxidative stress of human thyroid follicular epithelial cells. Histological evidence sh

SUBMITTER: Gong HZ 

PROVIDER: S-EPMC11315151 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature