Development and validation of prognostic signatures of NAD+ metabolism and immune-related genes in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a prevalent cause of death from malignant tumors. This study aimed to develop a nicotinamide adenine dinucleotide (NAD+) metabolism and immune-related prognostic signature, providing a theoretical foundation for prognosis and therapy in CRC patients.

Methods

NAD + metabolism-related and immune-related subtypes of CRC patients were identified by consistent clustering. Differentially expressed genes (DEGs) between the two subtypes of CRC were identified by overlapping. A risk signature was constructed using univariate Cox and least absolute shrinkage and selection operator (LASSO) regression analyses. Independent prognostic predictors were authenticated by Cox analysis. Gene set variation analysis (GSVA) and single-sample gene set enrichme

SUBMITTER: Ye T 

PROVIDER: S-EPMC11315184 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature