Multi-discrimination exposure and biological aging: Results from the midlife in the United States study.

ABSTRACT: Discrimination is a social determinant of health and health disparities for which the biological mechanisms remain poorly understood. This study investigated the hypothesis that discrimination contributes to poor health outcomes by accelerating biological processes of aging. We analyzed survey and blood DNA methylation data from the Midlife in the United States (MIDUS) study (N = 1967). We used linear regression analysis to test associations of everyday, major, and workplace discrimination with biological aging measured by the DunedinPACE, PhenoAge, and GrimAge2 epigenetic clocks. MIDUS participants who reported more discrimination tended to exhibit a faster pace of aging and older biological age as compared to peers who reported less discrimination. Effect-sizes for associations tended to

SUBMITTER: Cuevas AG 

PROVIDER: S-EPMC11315217 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature