Analysis of Groucho-histone interactions suggests mechanistic similarities between Groucho- and Tup1-mediated repression.

ABSTRACT: The Drosophila Groucho (Gro) protein is the defining member of a family of metazoan corepressors that have roles in many aspects of development, including segmentation, dorsal/ventral pattern formation, Notch signaling, and Wnt/Wg signaling. Previous speculation has suggested that Gro may be orthologous to the yeast corepressor Tup1. In support of this idea, a detailed alignment between the C-terminal WD-repeat domains of these two proteins shows that each Gro WD repeat is most similar to the Tup1 WD repeat occupying the corresponding position in that protein. Our analysis of Gro-histone interactions provides further support for a close evolutionary relationship between Gro and Tup1. In particular, we show that, as with the N-terminal region of Tup1, the N-terminal region of Gro is necessa

SUBMITTER: Flores-Saaib RD 

PROVIDER: S-EPMC113153 | biostudies-literature | 2000 Nov

REPOSITORIES: biostudies-literature