Development and implementation of a core genome multilocus sequence typing scheme for <i>Haemophilus influenzae</i>.

ABSTRACT: Haemophilus influenzae is part of the human nasopharyngeal microbiota and a pathogen causing invasive disease. The extensive genetic diversity observed in H. influenzae necessitates discriminatory analytical approaches to evaluate its population structure. This study developed a core genome multilocus sequence typing (cgMLST) scheme for H. influenzae using pangenome analysis tools and validated the cgMLST scheme using datasets consisting of complete reference genomes (N = 14) and high-quality draft H. influenzae genomes (N = 2297). The draft genome dataset was divided into a development dataset (N = 921) and a validation dataset (N = 1376). The development dataset was used to identify potential core genes, and the validation dataset w

SUBMITTER: Krisna MA 

PROVIDER: S-EPMC11315579 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature