Inhibition and potentiation of the exercise pressor reflex by pharmacological modulation of TRPC6 in male rats.

ABSTRACT: We determined the role played by the transient receptor potential canonical 6 (TRPC6) channel in evoking the mechanical component of the exercise pressor reflex in male decerebrated Sprague-Dawley rats. TRPC6 channels were identified by quadruple-labelled (DiI, TRPC6, neurofilament-200 and peripherin) immunohistochemistry in dorsal root ganglion (DRG) cells innervating the triceps surae muscles (n = 12). The exercise pressor reflex was evoked by statically contracting the triceps surae muscles before and after injection of the TRPC6 antagonist BI-749327 (n = 11; 12 μg kg^-1) or SAR7334 (n = 11; 7 μg kg^-1) or the TRPC6 positive modulator C20 (n = 11; 18 μg kg^-1). Similar experiments were conducted while the muscles were passively stretched (n = 8-12), a manoe

SUBMITTER: Ducrocq GP 

PROVIDER: S-EPMC11315811 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature