Hydrolysis of oligosaccharides in the gastrointestinal tract alters their prebiotic effects on probiotic strains.

ABSTRACT: Oligosaccharides have been widely used as prebiotics in the food industry, however their properties have been examined in vitro, without considering hydrolysis in the human digestive tract, especially in the small intestine. Here, we hypothesized that the prebiotic effects and utilization efficiency of ingested oligosaccharides would be altered in the colon, as their structures are partially hydrolyzed during digestion. Different types of oligosaccharides were partially degraded during simulated digestion, and digestible monosaccharides were released from the initial substrates. The growth of some probiotic strains responded to the presence of digestible/absorbable mono- and disaccharides (components of the prebiotic oligosaccharides), but not to that of the oligosaccharides themselves. Th

SUBMITTER: Lee WM 

PROVIDER: S-EPMC11315819 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature