Direct serotonin release in humans shapes aversive learning and inhibition.

ABSTRACT: The role of serotonin in human behaviour is informed by approaches which allow in vivo modification of synaptic serotonin. However, characterising the effects of increased serotonin signalling in human models of behaviour is challenging given the limitations of available experimental probes, notably selective serotonin reuptake inhibitors. Here we use a now-accessible approach to directly increase synaptic serotonin in humans (a selective serotonin releasing agent) and examine its influence on domains of behaviour historically considered core functions of serotonin. Computational techniques, including reinforcement learning and drift diffusion modelling, explain participant behaviour at baseline and after week-long intervention. Reinforcement learning models reveal that increasing synaptic

SUBMITTER: Colwell MJ 

PROVIDER: S-EPMC11315928 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature