Combinatorial regulatory states define cell fate diversity during embryogenesis.

ABSTRACT: Cell fate specification occurs along invariant species-specific trajectories that define the animal body plan. This process is controlled by gene regulatory networks that regulate the expression of the limited set of transcription factors encoded in animal genomes. Here we globally assess the spatial expression of ~90% of expressed transcription factors during sea urchin development from embryo to larva to determine the activity of gene regulatory networks and their regulatory states during cell fate specification. We show that >200 embryonically expressed transcription factors together define >70 cell fates that recapitulate the morphological and functional organization of this organism. Most cell fate-specific regulatory states consist of ~15-40 transcription factors with similarity part

SUBMITTER: Valencia JE 

PROVIDER: S-EPMC11315938 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature